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Exploiting the 2 Amino 1 3 4 thiadiazole Scaffold To

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Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery .

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery 14 09 2017 HITS gGmbH Heidelberg Institute for Theoretical Studies Schloss-Wolfsbrunnenweg 35 Germany Mail: ...

Fraunhofer-Publica List: Reinshagen,

Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster ... 2017 Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma ...

1,3,4-thiadiazole - an overview | ScienceDirect Topi

The aza-Wittig reaction is used twice in the preparation of bicyclic 1,3,4-thiadiazoles < 04S1067 >. Thus the isothiocyanates 262, obtained from aza-Wittig reactions of vinyliminophosphoranes 261 with sulphur disulfide, react with hydrazine to give 3-amino-2-thioxo-4 ...

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Pteridine Reductase in Support of Early-Stage Drug Discovery. | PubFac

PubFacts seeks to make the world's scientific research easy to locate, access, and collaborate on. ... David M Costa Portugal IBMC-Institute for Molecular and Cell Biology

RCSB PDB - 4WCD: Trypanosoma brucei PTR1 in complex with inhibitor

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Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery - ACS .

Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of Leishmania major PTR1 for activity against Trypanosoma brucei (Tb). We solved ...

Future in the Treatment of Parasitic Diseases: 2 Amino 1,3,4 Thiadiazoles in Leishmanias

bioavailability. This review presents synthetic 2‐amino‐1,3,4‐thiadiazole derivatives with antileishmanial activity. Many reported derivatives can be considered as lead compounds for the synthesis of future agents as an alternative to the treatment of leishmaniasis ...

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agent

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. ... View This Abstract Online 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial ...

NOVEL HETEROCYCLES BASED ON 1, 3, 4- THIADIAZOLE SCAFFOLD AS INSECTICIDES [

NOVEL HETEROCYCLES BASED ON 1, 3, 4-THIADIAZOLE SCAFFOLD AS INSECTICIDES [2] Madkour, H. F.(1) ... Thus, the authors utilized 2-amino-5-(2-chlorophenyl)-1, 3, 4-thiadiazole (1a) and 2-amino-5-(4-iodophenyl)-1,3,4-thiadiazole (1b) as versatile ...

Dawson, Alice — Discovery - the University of Dundee Research Port

2 Similar Profiles Trypanosoma brucei brucei Medicine & Life Sciences 2-amino-1,3,4-thiadiazole Chemical Compounds Lipid A Medicine & Life Sciences Binding Sites Medicine & Life Sciences CTP synthetase Medicine & Life Sciences Medicine & Life ...

[Full text] 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimi | DD

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea ...

Alice Dawson's research works | University of Dundee, Dundee and other plac

Alice Dawson's 9 research works with 3 citations and 257 reads, including: Supporting Info 4: Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

RCSB PDB - 5IZC: Trypanosoma brucei PTR1 in complex with inhibitor F0

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ...

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Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. By ...

3. Antileishmanial Activity Associated with 2-Amino-1,3,4-thiadiazole Syst

This review presents synthetic 2-amino-1,3,4-thiadiazole derivatives with antileishmanial activity. Many reported derivatives can be considered as lead compounds for the synthesis of future agents as an alternative to the treatment of leishmaniasis ...

1,2,4-thiadiazole - an overview | ScienceDirect Topi

3-Amino and 5-amino-1,2,4-thiadiazoles both exist predominantly in the amino forms. The IR spectrum of 5-mercapto-1,2,4-thiadiazole does not show a clear SH absorption as would be expected for structure ...

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery - The .

Year; Author; Type; University home > Repository; Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Dru

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimi | DD

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea ...

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Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit <i>Trypanosoma brucei </i>Pteridine Reductase in Support of Early-Stage Drug Discovery By Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro Da Silva ...