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Organisation of the human gene for O6 methylguanine DNA

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MGMT - Methylated-DNA--protein-cysteine methyltransferase - Homo sapiens (Human) - MGMT gene & prote

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. ... Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM Human entries with ...

Organisation of the human gene for O6-methylguanine-DNA methyltransfera

O6-Methylguanine-DNA methyltransferase plays an important role in cellular defence against mutagens and carcinogens with alkylating activity. Certain tumor-derived cell lines, ter

p53-mediated down-regulation of the human DNA repair gene O 6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription .

p53-mediated down-regulation of the human DNA repair gene O 6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor Dora Bocangel, Shiladitya Sengupta, Sankar Mitra, ...

“MGMT for pt mgmt”: Is Methylguanine-DNA Methyltransferase Testing Ready for Patient Management? - The Journal of Molecular Diagnosti

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. ...

Association of O6-Methylguanine-DNA Methyltransferase Protein Expression With Postoperative Prognosis and Adjuvant ...- JAMA Netwo

Inactivation of the DNA repair gene O 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. ...

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone | Oncoge

Activation of human O 6 -methylguanine-DNA methyltransferase gene by glucocorticoid hormone Activation of human O 6 -methylguanine-DNA methyltransferase gene by glucocorticoid hormone ...

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer — 九州大

An enzyme, O 6-methylguanine-DNA methyltransferase, is present in various organisms, from bacteria to human cells, and appears to be responsible for preventing the occurrence of such mutations. The enzyme transfers methyl groups from O ...

Direct Repair of O-methylguanine by Suicidal Enzyme - YouTu

One of major lesions in DNA caused by alkylating mutagens is O6-methylguanine leading to mutations and cancerous cells. This is repaired by a ubiquitous suicidal enzyme, O6-methylguanine DNA methyltransferase (MGMT or AGT). This movie shows the structure of human enzyme bound and flip the methylguanine residue ready to ...

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer — 九州大

present in various organisms, from bacteria to human cells, and appears to be responsible for preventing the occurrence of such ... agents. To counteract such effects, organisms possess a mechanism to repair O6-methylguanine in DNA. An enzyme, O6 ...

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase - ScienceDire

O 6-Methylguanine-DNA methyltransferase plays an important role in cellular defence against mutagens and carcinogens with alkylating activity. Certain tumor-derived cell lines, termed Mer −, are defective in the enzyme activity and have an increased sensitivity to ...

“MGMT for pt mgmt”: Is Methylguanine-DNA Methyltransferase Testing Ready for Patient Management? - The Journal of Molecular Diagnosti

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. ...

O6-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitio

O 6-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association ... Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss ] ...

Inhibition of Human O6-Methylguanine-DNA Methyltransferase by 5-Methylcytosi

[CANCER RESEARCH 54, 327-329, January 15, 1994] Advances in Brief Inhibition of Human O6-Methylguanine-DNA Methyltransferase by 5-Methylcytosine S. Stephen Bentivegna ~ and Edward Bresnick 2 Department of Pharmacology and Toxicology ...

Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event ...- Cancer Resear

Inactivation of the DNA Repair Gene O 6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event in Primary Human Neoplasia ...

Organization and Expression of the Mouse Gene for DNA Repair Methyltransferase | DNA and Cell Biolo

ABSTRACT O6-Methylguanine-DNA methyltransferase (MGMT) is present in various organisms, from bacteria to human cells, ... Organization and Expression of the Mouse Gene for DNA Repair Methyltransferase TOMOO IWAKUMA AKIKO SHIRAISHI ...

WO1994029454A1 - Plasmid for producing sense and anti-sense rna probes of the human mgmt gene - Google Paten

A plasmid is disclosed for producing sense and anti-sense RNA probes of the human O6-methylguanine-DNA-methyltransferase gene (MGMT gene). Alkyltransferase gene is also ...

The role of methylation and chromatin structure in the regulation of the O6-methylguanine-DNA methyltransferase (MGMT) gene in human glioma cel

Costello, Joseph F., "The role of methylation and chromatin structure in the regulation of the O6-methylguanine-DNA methyltransferase (MGMT) gene in human glioma ...

Promoter methylation of O6-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53 — 臺北醫學大

Methylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with G:C to A:T transitions in the p53 gene in various human cancers, including lung cancer. In tumors with p53 mutation, MGMT promoter methylation is more common in ...

Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Revie

is an abundantly expressed nuclear protein dealkylating O6-methylguanine (O6-MG) DNA residue, ... Baylin SB and Herman JG: Inactivation of the DNA repair gene O 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a 26 ...

RCSB PDB - 4BHC: CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIA

Human Gene View Pathway View Analyze Sequence & Structure Alignment Protein Symmetry Structure Quality Map Genomic Position to Protein PDB Statistics EPPIC Biological Assemblies ...

WikiGenes - MGMT - O-6-methylguanine-DNA methyltransfera

The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. ... Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter ...